![]() Mutations G880S, C862R, and C908R, situated within the second hybrid domain, disrupted the ratio of α-helix to β-sheet leading to a more compact conformation. Biophysical and biochemical approaches, including small angle x-ray scattering, analytical ultracentrifugation, and circular dichroism, were used to study the impact of these mutations upon the structure and function of the protein. To elucidate the genotype to phenotype correlations, we engineered four Marfan syndrome causing mutations into a fibrillin-1 fragment encoded by exons 18-25, a region known to interact with tropoelastin. The multiorgan involvement and wide spectrum of associated phenotypes highlights the complex pathogenesis underlying Marfan syndrome. Mutations in fibrillin-1 result in Marfan syndrome, which affects the cardiovascular, skeletal and ocular systems. These data demonstrate for the first time new requirements for microfibril biogenesis and identify at least two distinct molecular mechanisms associated with disease substitutions in the TB3-cbEGF18 region incorporation of mutant FBN1 into microfibrils changing their integral properties (cMFS) or the blocking of wild type FBN1 assembly by mutant molecules that prevents late-stage lateral assembly (nMFS). Additional analysis of a domain deletion variant caused by exon skipping also indicates that register in the neonatal region is likely to be critical for assembly. Microfibril incorporation by the nMFS variants was greatly reduced or absent compared to the cMFS forms, however, suggesting that nMFS substitutions disrupt a previously undefined site of microfibril assembly. In the majority of cases, both nMFS- and cMFS-associated neonatal region variants were secreted at levels comparable to wild type. To gain insight into the process of fibril assembly and increase our understanding of the mechanisms determining disease severity in MFS, we compared the secretion and assembly properties of FBN1 variants containing nMFS-associated substitutions with variants associated with milder, classical MFS (cMFS). Mutations associated with nMFS generally affect a region of FBN1 between domains TB3-cbEGF18-the "neonatal region". It features a wide spectrum of disease severity, from mild cases to the lethal neonatal form (nMFS), that is yet to be explained at the molecular level. Marfan syndrome (MFS) is a common inherited connective tissue disorder, caused by FBN1 mutations. The human FBN1 gene encodes fibrillin-1 (FBN1) the main component of the 10–12 nm diameter extracellular matrix microfibrils. ![]()
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![]() Output Layer Configuration: One node with a sigmoid activation unit.the class that you assign the integer value 1, whereas the other class is assigned the value 0. The problem is framed as predicting the likelihood of an example belonging to class one, e.g. Loss Function: Mean Squared Error (MSE).Ī problem where you classify an example as belonging to one of two classes.Output Layer Configuration: One node with a linear activation unit.179, Deep Learning, 2016 Machine Learning/Deep Learning Problems Regression ProblemĪ problem where you predict a real-value quantity. This means that the cost function is described as the cross-entropy between the training data and the model distribution. Most modern neural networks are trained using maximum likelihood. 156, Neural Smithing: Supervised Learning in Feedforward Artificial Neural Networks, 1999 The mean squared error is popular for function approximation (regression) problems The cross-entropy error function is often used for classification problems when outputs are interpreted as probabilities of membership in an indicated class. The optimization strategies aim at minimizing the cost function.Ī few basic functions are very commonly used. A cost function, on the other hand, is the average loss over the entire training dataset. It is also sometimes called an error function. , Deep Learning, 2016Ī loss function is for a single training example. When we are minimizing it, we may also call it the cost function, loss function, or error function. Multi-Class Multiple Label:įor this case, we can apply the softmax loss with a little modification.The function we want to minimize or maximize is called the objective function or criterion. It is a Softmax activation plus a Cross-Entropy loss. the number of categories is large to the prediction output becomes overwhelming.Īlso called Softmax Loss.you don’t care at all about other close-enough predictions, when your classes are mutually exclusive, i.e.There are a number of situations to use scce, including: Many categorical models produce scce output because you save space, but lose A LOT of information (for example, in the 2nd example, index 2 was also very close.) I generally prefer cce output for model reliability. In the case of scce, the target index might be, and the model may predict.In the case of cce, the one-hot target might be and the model may predict (probably inaccurate, given that it gives more probability to the first class).Ĭonsider now a classification problem with 3 classes. In the case of scce, the target index may be and the model may predict.In the case of cce, the one-hot target may be and the model may predict (probably right).sparse_categorical_crossentropy ( scce) produces a category index of the most likely matching category.Ĭonsider a classification problem with 5 categories (or classes). ![]() categorical_crossentropy ( cce) produces a one-hot array containing the probable match for each category,.In this case, we can calculate using two different methods: Categorical Cross-Entropy and Sparse Categorical Cross-Entropy. Multi-Label can classify multiples objects in one sample. Multi-Class only classify one object from multiples objects in one sample. Difference between Multi-class and Multi-label. ![]() ![]() ![]() Follow the steps to set it as your default player. Select Ask before Setting Default Apps.Ĩ. If you own an Android or iPhone, first you will need to download VLC from their respective stores. Setting VLC as the Default Player (Android and iOS) Tap Change All to ensure this setting applies to all files of this type. Move your mouse down to Open With and select VLC. For this tutorial, I’m going to use an Mkv file.ģ. You can just do this by accessing any random media file.ġ. In MAC, you don’t necessarily have to open VLC to set it to default. In some editions of Windows 10, its included as an optional feature that you can enable. Select Select All, or you can tick the boxes of the specific files you wish to run with VLC. You can search VLC on Google, and you will find the Softonic link for the software. Windows Media Player Windows NT 4.0 Mac OS 7 Mac OS X Solaris Windows 3.0 MM and Windows 3.1 Windows 9x Windows 2000, Windows ME, Windows XP, Windows. You can also see the rating, pros, and cons of the VLC. When you upload software to you get rewarded by points. It is a popular source for downloading software. Scroll down, and choose Set up Associations.ĥ. It is another website, which is a reliable source for downloading VLC. By default, the Interface tab will open up. Select Preferences from the drop-down menu.Ĥ. /rebates/&.com252fmac252ftop-six-media-converter-mac. Go to Tools, situated on the top panel.ģ. Setting VLC as the Default Player (Windows)Ģ. Media Composer video editing software is the industrys best video editor and finishing software for movie, TV, and indie production. Whatever the case, in this tutorial, we will show you how to make the latest version of VLC your default media player in Windows, Android, Mac, every platform. Window’s media player can do this by prompting you to set it to default instead of VLC every time it is opened. When you install it, you get the option to do this, but these preferences can easily revert. However, despite these kickass features, it’s not always set to default. It can play almost every video format and has better sound amplifiers than any other media player in the world. Use it to play all your media with ease.Let’s say it out loud: VLC is the best media player. VLC Media Player will launch for the first time.Provide it the permissions if your Mac computer asks for it. Double click on VLC media player (the icon with the cone).VLC will be copied to your applications folder.Click and drag the VLC icon to the applications folder.After verifying the contents of the file, it will open. Locate the downloaded file which will be named something like vlc-2.1.0.dmg.Download VLC installation file from the location mentioned above (VideoLAN website). ![]() They require the OS X version to be 10.5 or lower. The plugins are available for Intel Mac and Power Mac users. Need to upgrade to DivX Player Pro to unlock advanced video playing features. Cons DivX Player does not work with macOS Catalina and later versions. Stream HD and common video files to DLNA-compatible devices, including PS3, Xbox, Chromecast, and more. ![]() Those are for playing/streaming videos straight from your browser. DivX Player is a free HD file player for Windows 10/8/7 and Mac. Keep the original quality of audio tracks and music. You will also see two web browser plugin download links. Key features: Read M3U8 files and let you to listen to music simply. PowerPC Mac: Dmg package for 32 bit PowerPC Mac OS X 10.5 Leopard users. VLC for Mac OS X: 64 bit VLC dmg package download link which works for Mac OS X 10.6 and later.ģ2 bits Intel Mac: This dmg package is for 32 bit Intel Mac OS X 10.5 Leopard users. It has support for almost any type of video output from DVDs to VCDs and YouTube videos it can go over the internet or local area networks (LAN), play audio CDs with CD+G. You will see different download links for: VLC Media Player is a free and open-source media player that plays most multimedia files as well as discs, devices, and network streaming protocols. Downloading for Macīasically, you download a dmg package for your Mac computers from the following page: Read the instructions below to understand how you will be able to install VLC in your Mac. Different versions of the player is required for a different Mac OS X version and the VideoLAN team has got it covered. The software is freely available for Mac OS X systems. It runs on most popular Macintosh models, including the Apple iMac, Cube and G4. This free and awesome player is readily available for Apple computer users. Player 7 for Mac, which offers Macintosh users access to the thousands of hours of the highest-quality movies and music available in Windows Media Format, a new and intuitive design and reliable performance. VLC Media Player is available on several popular platforms. ![]() ![]() ![]() Bug:54079 - " Add unichrome.sf.net driver" status:RESOLVED resolution:OBSOLETE severity:enhancement.Bug:53897 - " dev-java/jdic - The JDesktop Integration Components (JDIC)" status:RESOLVED resolution:OBSOLETE severity:enhancement.Bug:52471 - " biditext" status:RESOLVED resolution:OBSOLETE severity:enhancement. ![]()
![]() Still can’t tell? If you’re not sure if the small bump is a tick or a skin tag, ask your vet to check it to be on the safe side. Then, disinfect the patch of skin with 70 isopropyl alcohol. Growth – If it gets bigger over a period of a few days, it may be more likely to be a tick rather than a skin tag. On dogs, the most common type of cancer are tumors of the skin and the tissues beneath the skin known as subcutis. Prepare to cut your dogs skin tag by clipping their fur in the surrounding area.If the tick isn’t yet attached, it may run away from you, so be careful to examine your pet outside your home just in case you lose sight of the little critter. A black skin tag on your dog’s leg, or finding blackheads on their belly, for example, should be evaluated quickly. Try touching the tick with a gloved finger and watch to see any legs moving. Movement – Even an attached tick will move their legs when provoked.Legs – Ticks are part of the arachnid family, so just like spiders, adult ticks have eight legs which you should be able to see on closer inspection. ![]() Although skin tags on dogs skin are disturbing and unpleasant to look at, they are not cancerous. B Its a tag attached to a dogs skin with a registration number for breeding specimens. They’re most common in parts where friction is. A Its a tag embedded in the dogs skin for identification purposes. These growths can develop in many areas on your body. Canine skin tags, also called fibropapillomas or achrochordons, are skin growths that can appear on any breed at any age. You may need to take a closer look using a magnifying glass if your dog has dark-coloured skin and fur. Can dogs get skin tags Yes, they can, just like humans. A skin tag is a flesh-colored growth that can be thin and stalky looking or round in shape. Spotting a tick over a skin tag is quite straight-forward if your pet has light-coloured skin and fur. Colour – Skin tags tend to be the same colour as your pet’s skin, while ticks are often dark brown or grey in colour.Here’s how you tell the difference between a tick and a skin tag: Suspected skin tags should be evaluated by a veterinarian, to rule out more serious concerns. The longer your pet has a tick attached, it increases the risk of your pet contracting a disease. Could that bump on your dog’s body be a skin tag or is it a tick? While skin tags are perfectly normal, it’s important to identify a tick early on, so you can remove it as soon as possible. ![]() ![]() ![]() “A letter to Congress shared with Motherboard shows that the US National Security Agency, the Central Intelligence Agency, and other members of the Intelligence Community use ad blockers on their networks as a security protection. In this case, I clicked on an advertisement (on purpose) and since I was interested in the products offered in the ad, I disabled the block temporarily. I can choose to disable the block temporarily or permanently. In the screenshot above, you can see when I clicked a link on a site I trust that I am being redirected to another site. A redirect happens when you click a link on a site you trust – one that you assume leads to a safe website – that may lead you to a questionable website. UBlock Origin blocks potentially dangerous “redirects”Īnd another good reason to install uBlock Origin is that it will block redirects that may lead you into troubled waters. And if those kinds of ads are blocked, you don’t have to worry about panicking and clicking something you shouldn’t, right? To make a long story shorter – I installed uBlock Origin on his computer so that the chances he will ever see such an ad again is just about zero. Of course, there are no vir,uses to begin with - it’s all a scam. Not everyone knows what to do when assaulted by such an ad and panic… they’ll click to run the scan and then find out they have to pay to clean all these viruses. I knew what to do and immediately closed the ad. The other day I was fixing a computer remotely with our Cloudeight Direct computer care session I was using the customer’s browser to check something when all of sudden I was greeted with a huge ad warning that his computer was infected with 406 viruses and urging him to run a scan. We’ve featured uBlock Origin before, and now we have even more reasons to use and recommend uBlock Origin: It can help you stay safer on the web. While it’s true that most advertisements can be annoying, most are benign. We’ve noticed more often lately how many bad things can happen when advertisements are displayed. More Reasons Why You Should be Using uBlock Origin ![]() ![]() ![]() ![]() This website contains public sector information licensed under the Open Government Licence v2.0.Total number of accesses of a patient record by an 'online patient' with Detailed Coded Care Record access. Our website also provide detailed information about General Practices which is easy to comprehend and freely accessible. GP practices should make information about their services easily available to their patients. Practices also work closely with other healthcare professionals, such as health visitors, midwives, mental health services and social care services. What is a GP Practice? : GPs usually work in practices (a physical location / clinic) as part of a team that includes nurses, healthcare assistants, practice managers, receptionists and other staff. So, if they can't deal with any particular medical condition, they refer the patient to the specialized hospital for tests, treatment, or to see a consultant with specialist knowledge. GPs are not specialized in any one particular area. They also provide advice on diet and smoking, preventive care and health education to patients. GPs provide routine health care checkups like physical examinations, vaccinations, simple surgical operations etc. What are GPs? : GP stands for 'General Practitioner' who can deal with all type of medical conditions and mainly treats acute (short duration) and chronic (diseases that lasts for more than three months) illnesses. Total number of accesses of a patient record by an 'online patient' with Detailed Coded Care Record access. Total number of 'online patients' registered to use an online Patient Record Access Service to access elements of the Detailed Coded Care Record Patients can view detailed coded records online (Note that ordering several items at once to be counted as one prescription).įunctionality status of the Practice system for enabling the use of online Patient Record Access Services for 'online patients' to view their Detailed Coded Care Record Total number of prescriptions ordered using an Online Patient Transaction Service. Total number of 'online patients' registered to use an online Patient Transactional Service to order repeat prescriptions Total number of appointment scheduling or cancelling transactions using an Online Patient Transaction Service within the reporting monthįunctionality status of the online system at the Practice for enabling the use of online Patient Transactional Services for ordering repeat prescriptions through the Principal system ![]() Total number of 'online patients' registered to use an online Patient Transactional Service to book and/or cancel appointments Online booking of appointments and cancelling can be allowed but GP has not yet enabled the functionality ![]() Patient Online Management Information Silverlock Medical Centre has total of 15227 registered patients as per Patient Online Management Information (POMI) system as on 30-Sep-22įunctionality status of the online system at the Practice for enabling the use of online Patient Transactional Services for booking and/or cancelling appointments through the Principal system Stroke prevention: medication for patients with atrial fibrillation Proportion of children aged 2 with pneumococcal conjugate booster vaccine Proportion of children aged 2 with Measles, Mumps and Rubella vaccine Proportion of children aged 2 with Haemophilus influenzae type b and Meningitis C booster vaccine Percentage of children aged 1 completed primary course of 5:1 vaccine Patient Satisfaction with GP Practice Appointment TimesĤ9.06% were satisfied, of 101 respondents. Patient Experience - Confidence and Trust in healthcare professionalĩ7.90% had confidence, of 95 respondents. Mental Health – Comprehensive Care Planning Items per standardised prescribing unit (see definition)ħ1.43% detected by practice, out of 14 new diagnoses.Ĭare Quality Commission Inspection RatingsĨ9.66% reviewed by GP, out of 29 patients diagnosed.ĭiabetes - Managing Blood Glucose Level (HbA1c)Ĩ2.63% within a recommended level, out of 259 patients.įlu vaccinations - Aged 65 and over groupħ1.0% vaccinated, of 345 eligible people.įlu vaccinations - Under 65 At Risk Groupsĥ8.8% vaccinated, of 371 eligible people.Ĩ3.85% with recommended measurement, out of 650 patients. Performance Some measuring parameters of Silverlock Medical Centre are taken and their fetched values are as mentioned below. ![]() ![]() I use Pages, TextWrangler, and (rarely these days) Mellel. But the flexibility afforded by Pages makes it the winner on the Mac, not iA Writer. It provides all the flexibility (simple or sophisticated) I need, albeit without one or two nice features found in iA Writer. But I use 24-27" monitors, quite different animals.įrankly, Pages in full screen mode is pretty terrific. I can't.īut, on a MacBook Air iA Writer will no doubt shine pretty well. Further, with a large screen, I would like to adjust the margin sizes, top, bottom and sides. For example, I would like to sometimes view the text in a larger size (my eyes are getting old). The Mac form factor, especially with a large screen, requires more flexibility. On the Mac, with it's very different form factor, iA Writer simply does not shine. I am a big supporter of iA Writer on the iPad, and bought the Mac product. For $9.99 it's a rip off when you can use free alternatives already installed or much better alternatives. ![]() It is a first year high school project at best. Last year I donated to OmmWriter Dāna II and never felt cheated for the hard work and a truly unique minimalistic writing tool. I wasn't impressed I was being used as a guinea pig for unfinished software that cost more money than it will ever be worth. ![]() IA Writer is as polished as a high school kid's weekend programming project. My applications folder has installed stickies and textedit that offered more stabilty and real world features. I felt cheated after 5 minutes and demanded a refund from apple. How did I like iA Writer? $9.99 for a minimalistic writing tool. I purchased the app after giving up trying to navigate the app store manually and used the search box. Any other email I recieve within seconds but this email from apple took over 30 minutes. Without the validation email I wasn't allowed to login or make purchases yet. ![]() Purchasing this app was my first experience with app store or as others call it correctly the crap store.Īfter what seemed like hours I finally got my app store account working correctly with my credit card and the validation email was finally sent to my email box. Where to even begin with this adventure into idiot-land. ![]() ![]() ![]() For Shift Admin customers, uniting with QGenda strengthens the value of our services by expanding access to customer success resources and more capabilities to optimize provider schedules, streamline workflows, and improve access to care,” stated Dr. “We are thrilled to join forces with QGenda and collaborate to advance workforce management for healthcare organizations. ![]() ![]() The QGenda platform also includes solutions for on-call scheduling, room management, time tracking, compensation management, and workforce analytics. Recommended AI News: Dominion DMS Announces VUE Integration with Kia Motorsīy adding the leading provider in shift-based scheduling, QGenda is enhancing capabilities for emergency medicine, hospital medicine, and urgent care, while building upon its industry-leading scheduling solution for providers in specialties such as anesthesia, radiology, cardiology, obstetrics & gynecology, and pathology. Compare features, ratings, user reviews, pricing, and more from Shift Admin competitors and alternatives in order to make an informed decision for your business. SourceForge ranks the best alternatives to Shift Admin in 2022. We are partnering with customers to deliver greater visibility into where and when providers are working and optimizing capacity to deliver quality, cohesive care across the entire organization,” stated Greg Benoit, CEO of QGenda. Compare Shift Admin alternatives for your business or organization using the curated list below. QGenda, with the addition of Shift Admin’s shift-based provider scheduling capabilities, is helping healthcare organizations address these priorities. “With care needs fluctuating across states and even within the same area, transparency and flexibility continue to be a large need for healthcare organizations nationwide. Recommended AI News: Interxion: A Digital Realty Company Collaborates With PCCW Global To Deliver Submarine Cable Gateway To Europe By scheduling for all providers and specialties through QGenda, organizations have greater access to data, details, and insights for thousands of providers working across the system. Today’s announcement furthers QGenda’s commitment to advancing how healthcare organizations manage and schedule their workforce so they can effectively use providers’ time, reduce burnout and optimize capacity. With the industry-leading scheduling technology for all specialties across the healthcare delivery system, QGenda’s technology will serve as the single source of truth for all provider schedules, ensuring care is available for patients when and where it is needed. To perform automated scheduling, you will usually want to know which shifts in the schedule each provider has requested not to work. QGenda, the leading innovator in enterprise healthcare workforce management solutions, announced the acquisition of Shift Admin, an industry-recognized leader for shift-based specialties including emergency medicine, urgent care, and hospital medicine. Download Shift Admin and enjoy it on your iPhone, iPad, and iPod touch. As a combined organization, QGenda is helping more healthcare organizations maximize provider time, optimize capacity, and improve patient access to care ![]() ![]() ![]() The system is expected to reach the coast of northeastern Mexico late Saturday afternoon, pushing inland through Sunday. Over 90% of the state of Texas is currently experiencing drought conditions, with nearly 62% experiencing extreme or exceptional drought conditions – the highest categories. “Urban areas will be the most vulnerable to flooding for the period even with the extremely dry, drought conditions.” Rainfall nearing 2 to 3 inches per hour is possible, according to the WPC. The plume of moisture and heavy rainfall is expected to move into northern Texas beginning Sunday into Monday – where a level 2 out of 4 “slight risk” for excessive rainfall has been issued. “Urban locations in addition to areas of complex terrain, slot canyons, arroyos, and burn scars are especially vulnerable for flash flooding and can quickly turn into very dangerous situations,” the WPC said on Saturday. See if rain is expected where you live right here > The flash flood at Zion National Park is associated with rain from the same system affecting the Southwest this weekend. The injured hiker was taken to a hospital, according to Shafer. “Park rangers found an injured hiker who had been pulled downstream several hundred yards,” Shafer said. Rangers were alerted about hikers being “swept off their feet” near the Temple of Sinawava on Friday afternoon, according to Zion National Park spokesman Jonathan Shafer. On Saturday, a search and rescue operation for a missing person continued at Zion National Park in Utah following a flash flood on the Virgin River, according to a tweet from the national park. Tropical storm warning issued for South Texas and the East Coast of Mexico ![]() |
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